This can be inferred from Rattmann reading a book called, "Art Therapy" in the comic Portal 2: Lab Rat. His scribbles and artwork on the walls could be a temporary fix to his illness. It also appears he had several Cubes, as his scribblings show him mourning over the loss of one. He spent hours scribbling on walls, painting murals, graffiti and arrows and hints for the day Chell would wake up and try to escape, and became obsessed with the Companion Cube that his schizophrenia made talk to him and give him advice, acting as his source of logic. Consequently, he slowly lost his sanity, his schizophrenia completely taking him over. Having only two pills left, he kept them for the day GLaDOS would wake Chell. Rattmann then spent the next several months surviving in the Test Chambers and maintenance areas of Aperture. Convinced she is the one he needs to stop GLaDOS, he put her on top of the Test Subject list, so that she would be the first to be picked in the next test. It said that she should not be tested, as she is abnormally stubborn and "never ever" gives up. He fled to the file room and found her file. She attempted to convince him that his situation was a result of his paranoia, but he ignored her, and got a hunch about a Test Subject, Chell, who he thought could make a difference. Rattmann was one of the only survivors, and GLaDOS turned onto taunting him about his schizophrenia. When GLaDOS was activated in 200-, she became self-aware, locked down the facility, and flooded the Enrichment Center with deadly neurotoxins.
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